The stimulation of CD4-positive, CD25-negative T cells by anti-CD3 antibodies or allogeneic mature dendritic cells in the presence of CD4-positive, CD25-positive T cells showed more anti-increasing in number effect dependent on the number of CD4-positive, CD25-positive T cells than the same stimulation in the absence of CD4-positive, CD25-positive T cells. The addition of cytokines such as IL-2, IL-4 and IL-15 to the stimulation by anti-CD3 and anti-CD28 antibodies increases the DNA synthesize ability of CD4-positive, CD25-positive T cells, but does not change that ability of CD4-positive, CD25-negative T cells. CD4-positive, CD25-positive T cells do not promote DNA synthesis or cytokine production after stimulation such as anti-CD3 antibody stimulation, stimulation by anti-CD3 and anti-CD28 antibodies or stimulation by allogeneic mature dendritic cells which indicates nonresponsiveness of the cells to antigenic stimulation. Furthermore, CTLA-4 is expressed steadily in the CD4-positive, CD25-positive cells and the expression level of CTLA-4 increases by stimulation. CD4-positive, CD25-positive T cells isolated from human peripheral blood express CD45RO-positive memory T cell markers, and their expression level of activation markers such as HLA-DR is higher than that of CD4-positive, CD25-negative T cells. It is known that similar CD4-positive, CD25-positive regulatory T cells are present in humans as well (non-patent references 12, 13, 14, 15, 16 and 17).
In autoimmune diseases, this immunological homeostasis function is lost and the resultant hyperimmune response to self antigen causes the diseases. As mentioned above, the body distinguishes between self and non-self antigens, and possesses a mechanism that eliminates only non-self antigens.
At the same time, immunological tolerance keeps the elimination mechanism from functioning against autoantigens which are component within the body. Normally, a healthy immune response mechanism eliminates foreign non-self antigens. The immune response relates to the elimination of pathogens and the acquirement of resistance to infection under a delicate balance through the functions of T cells of different characteristics. In general, Th1 cells and Th2 cells relate to biological defense, in the form of cell-mediated immunity and in the form of antibody-mediated immunity, respectively. CD4-positive helper T cells can be classified in accordance with their cytokine-production pattern in specific stage of mature differentiation following antigen stimulation into such as Th1 cells and Th2 cells, which primarily produce IFN-gamma and IL-4, respectively. T cells can be roughly divided into CD4-positive helper T cells and CD8-positive cytopathic T cells. JCI Insight 4:N/A (2019).T cells are one of the group of cells that play a central role in the immune system that defends the body against various pathogens. Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNA. BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3K/Akt-mTOR Pathway. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. ?9 -Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo. Publishing research using ab32760? Please let us know so that we can cite the reference in this datasheet.Īb32760 has been referenced in 21 publications.